Our computer prediction projects a lopsided win (28-14) for the Buffalo Bills (2-0) over the Jacksonville Jaguars (0-2) on Monday, Sept. 23 at Highmark Stadium (kickoff at 7:30 p.m. ET).Bills vs.

The Jacksonville Jaguars visit the Buffalo Bills for the first leg of a Monday Night Football doubleheader to close out Week 3 with a whole lot of questions swirling around it. Jacksonville lost 18-13 to the Cleveland Browns last week 18-13 — the same Browns that lost to the miserable New York Giants on Sunday — to drop to 1-1,

The Buffalo Bills Week 3 matchup with the Jacksonville Jaguars on Monday Night Football will have huge implications for the AFC this season. So, ahead of the Bills-Jaguars game, let’s make some bold Bills Week 3 predictions.