Buffalo Bills quarterback Josh Allen (17) calls a play in the huddle with guard David Edwards (76), tackle Dion Dawkins (73) and running back James Cook (4) during an NFL football game against the Miami Dolphins, Thursday, Sept. 12, 2024, in Miami Gardens, Fla. (AP Photo/Doug Murray) AP

The Bills have lived up to the hype, while the Jaguars have not. Josh Allen has played at an MVP level while leading Buffalo to a 2-0 record, while Trevor Lawrence and Jacksonville have sputtered to an 0-2 start.

Odds: The Jaguars are 5.5-point underdogs to the Bills, per BetMGM. The over/under is currently 45.5 points.