Real Salt Lake and Costa Rican side Herediano are deadlocked at 0-0 entering Leg 2 of their 2025 Concacaf Champions Cup Round One series, which will be decided Wednesday night at America First Field.

FC Cincinnati hold a 4-1 aggregate lead over Motagua ahead of hosting Leg 2 of their 2025 Concacaf Champions Cup Round One series on Wednesday night.

Seattle Sounders FC carry a 3-1 aggregate lead over Guatemalan side Antigua into Wednesday's decisive Leg 2 of their Concacaf Champions Cup Round One series.