Could scientists detect neurodegenerative diseases like Alzheimer's and ALS years or decades before these disorders manifest outward signs? What could researchers learn by following hundreds of ...

Synthetic hydrogel-based assay to study 3D confined cell migration. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adm9195 Eukaryotic cells—that is, cells with a nucleus—possess an astounding ...

Aggregation-prone proteins often misfold into multiple distinct amyloid conformations that dictate different physiological impacts. Although amyloid formation is triggered by a transient nucleus, the ...

A lattice model with side chains was used to investigate protein folding with computer simulations. In this model, we rigorously demonstrate the existence of a specific folding nucleus. This nucleus ...