NFL Week 7 betting spreads, lines, point totals for every game on the NFL Week 7 schedule, with odds for favorites and underdogs in each NFL matchup.

Drake Maye has arrived. The Patriots’ second-year quarterback is playing himself into the NFL MVP conversation, throwing for 1,744 yards with 12 touchdowns and just two interceptions through seven games.

Let's dive into all three prime-time matchups, and the most intriguing games in the early and late Sunday afternoon windows.

Get the opening NFL Week 8 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Oct. 23, 2025.