Activation of a specific part of the Dicer enzyme can change its shape in a way that affects its critical role in proper cell ...

Cancer incidence rises sharply with age, yet the biological mechanisms that make older patients more vulnerable to treatment failure remain poorly ...

Investigators from VHIO, which is part of the Vall Hebron Campus, publish the first study to address the impact of the exposome on early-onset colorectal cancer through epigenetic signatures. The ...

A person's lifetime risk for cancer may begin before they are even born, reports a paradigm-shifting study by Van Andel Institute scientists. The findings, published in Nature Cancer, identified two ...

Researchers are focusing on the differences between identical twins, rather than the similarities, in an attempt to rethink the nature versus nurture debate, and unlock medical mysteries including ...

Methylation and cancer While these papers looked at the role of chromatin in the genetic expression of cancers, there are other laboratories looking at the role of methylation, another epigenetic ...

A study led by José A. Seoane, Head of the Vall d'Hebron Institute of Oncology's (VHIO) Computational Biology Group ...

The role of epigenetic mechanisms in cancer has gained interest in recent studies. The reversible nature of epigenetic changes on genomic DNA and histones holds promise for the development of ...

In the early 1980s, the first changes in DNA related to a chemical modification called methylation were discovered, followed by the discovery in the mid-1990s of the first tumor suppressor genes ...

Epigenetic regulation has emerged as a crucial factor in tumour biology, fundamentally influencing gene expression without altering the underlying DNA sequence. Aberrant epigenetic modifications – ...

Chromatin is one of the earliest identified targets for cancer therapeutics. Drug development aimed at altering chromatin can be traced to the differentiating agents of the 1970s and their link to DNA ...

A new study suggests that a common pesticide, picloram, may contribute to growing rates of early onset colorectal cancer, asides from known risk factors such as smoking and diet.