Antisense oligonucleotide strategy reverses HNRNPH2-related neurodevelopmental disorder

Scientists at St. Jude Children's Research Hospital have found that they can reverse the effects of HNRNPH2-related ...
Monthly Prescribing Reference

Calpain-2 Targeting Antisense Oligonucleotide Fast Tracked for ALS

AMX0114 is an investigational antisense oligonucleotide targeting calpain-2, a calcium-activated protease believed to play a role in ALS disease progression. The Food and Drug Administration (FDA) has ...
BioWorld

Antisense oligonucleotide targeting nicotinamide N-methyltransferase as a potential cancer therapy

Researchers from Osaka University have developed a novel approach to target nicotinamide N-methyltransferase (NNMT), an enzyme implicated in cancer progression, using antisense oligonucleotides (ASOs) ...
The Scientist

Making sense of antisense

The specificity of antisense approaches is much debated and has hampered their development for clinical therapeutics. In the August 14 Proceedings of the National Academy of Sciences, Yee Cho and ...